crmPack (version 2.0.0)

NextBestMTD-class: NextBestMTD

Description

NextBestMTD is the class for next best dose based on MTD estimate.

Usage

NextBestMTD(target, derive)
.DefaultNextBestMTD()

Arguments

target

(proportion)
see slot definition.

derive

(function)
see slot definition.

Slots

target

(proportion)
target toxicity probability, except 0 or 1.

derive

(function)
a function which derives the final next best MTD estimate, based on vector of posterior MTD samples. It must therefore accept one and only one argument, which is a numeric vector, and return a number.

Examples

# In the example below, the MTD is defined as the dose for which prob(DLE) = 0.33
# and we will use the 25th quantile of the posterior of MTD as our next best dose.
next_best_mtd <- NextBestMTD(
  target = 0.33,
  derive = function(mtd_samples) {
    quantile(mtd_samples, probs = 0.25)
  }
)