Stopping-class

Stopping

<a href="https://lifecycle.r-lib.org/articles/stages.html#stable"><img src="figures/lifecycle-stable.svg?package=crmPack&version=2.0.0" alt="[Stable]"></a>
<code>Stopping</code> is a class for stopping rules.

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanes Bove et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

Stopping-class function

<dl>
<dt><code>report_label</code></dt>
<dd>(<code>string</code>) a label for the stopping report. The meaning
of this parameter is twofold. If it is equal to <code>NA_character_</code> (default),
the <code>report_label</code> will not be used in the report at all. Otherwise, if it
is specified as an empty character (i.e. <code>character(0)</code>) in a user constructor,
then a default, class-specific label will be created for this slot.
Finally, for the remaining cases, a user can provide a custom label.</dd></dl>

Slots

<a href='https://lifecycle.r-lib.org/articles/stages.html#stable'><img src='figures/lifecycle-stable.svg' alt='[Stable]' /></a>
<code>Stopping</code> is a class for stopping rules.

Stopping — Stopping-class

<dl>
<dt><code>report_label</code></dt>
<dd>(<code>string</code>) a label for the stopping report. The meaning
of this parameter is twofold. If it is equal to <code>NA_character_</code> (default),
the <code>report_label</code> will not be used in the report at all. Otherwise, if it
is specified as an empty character (i.e. <code>character(0)</code>) in a user constructor,
then a default, class-specific label will be created for this slot.
Finally, for the remaining cases, a user can provide a custom label.</dd>


</dl>

<code>Stopping</code>

Stopping-class: `Stopping`

Description

Arguments

Slots

See Also