v_design

v_rule_design

v_rule_design_ordinal

v_design_grouped

<a href="https://lifecycle.r-lib.org/articles/stages.html#stable"><img src="figures/lifecycle-stable.svg?package=crmPack&version=2.0.1" alt="[Stable]"></a>
These functions are only used internally to validate the format of an input
<code>RuleDesign</code> or inherited classes and therefore not exported.
<a href="https://lifecycle.r-lib.org/articles/stages.html#experimental"><img src="figures/lifecycle-experimental.svg?package=crmPack&version=2.0.1" alt="[Experimental]"></a>
These functions are only used internally to validate the format of an input
<code>RuleDesignOrdinal</code> or inherited classes and therefore not exported.

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanes Bove et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

v_design function

<dl><dt>object</dt>
<dd>(<code>RuleDesignOrdinal</code>) object to validate.</dd></dl>

Arguments

<ul>
<li><code>v_rule_design()</code>: validates that the <code>RuleDesign</code> object
contains valid <code>startingDose</code>.</li>
<li><code>v_rule_design_ordinal()</code>: validates that the <code>RuleDesignOrdinal</code> object
contains valid <code>starting_dose</code>.</li>
<li><code>v_design_grouped()</code>: validates that the <code>DesignGrouped</code> object
contains valid flags.</li>
</ul>

Functions

<a href='https://lifecycle.r-lib.org/articles/stages.html#stable'><img src='figures/lifecycle-stable.svg' alt='[Stable]' /></a>
These functions are only used internally to validate the format of an input
<code>RuleDesign</code> or inherited classes and therefore not exported.
<a href='https://lifecycle.r-lib.org/articles/stages.html#experimental'><img src='figures/lifecycle-experimental.svg' alt='[Experimental]' /></a>
These functions are only used internally to validate the format of an input
<code>RuleDesignOrdinal</code> or inherited classes and therefore not exported.

Internal Helper Functions for Validation of RuleDesign Objects — v_design

<dl>

<dt>object</dt>
<dd>(<code>RuleDesignOrdinal</code>) object to validate.</dd>

</dl>

Internal Helper Functions for Validation of <code>RuleDesign</code> Objects

v_design: Internal Helper Functions for Validation of `RuleDesign` Objects

Description

Usage

Value

Arguments

Functions