crmPack (version 2.1.0)

maxRecruits: Calculate Maximum Number of Backfill Patients

Description

Calculates the maximum number of backfill patients that can be recruited based on the recruitment rule and the active cohort size.

Usage

maxRecruits(object, active_cohort_size, ...)
# S4 method for RecruitmentUnlimited
maxRecruits(object, active_cohort_size, ...)
# S4 method for RecruitmentRatio
maxRecruits(object, active_cohort_size, ...)

Value

The maximum number of backfill patients as an integer.

Arguments

object

(Recruitment)
the recruitment rule.

active_cohort_size

(integer)
the current size of the active dose escalation cohort.

...

further arguments (not used).

Functions

• maxRecruits(RecruitmentUnlimited): method for RecruitmentUnlimited class. Returns a very large number (practically unlimited).

• maxRecruits(RecruitmentRatio): method for RecruitmentRatio class. Returns ceiling(ratio * active_cohort_size).

See Also

Recruitment, RecruitmentUnlimited, RecruitmentRatio.

Examples

# Create a RecruitmentUnlimited object
recruitment <- RecruitmentUnlimited()

# Calculate maximum recruits for various active cohort sizes
max_recruits_10 <- maxRecruits(recruitment, active_cohort_size = 10)
print(max_recruits_10) # Returns 1e6

max_recruits_100 <- maxRecruits(recruitment, active_cohort_size = 100)
print(max_recruits_100) # Still returns 1e6 (unlimited)

# With RecruitmentUnlimited, the active_cohort_size is ignored
# Create a RecruitmentRatio object with ratio 0.5
recruitment <- RecruitmentRatio(ratio = 0.5)

# Calculate maximum recruits based on active cohort size
# For active cohort of 10: ceiling(0.5 * 10) = 5
max_recruits_10 <- maxRecruits(recruitment, active_cohort_size = 10)
print(max_recruits_10) # 5

# For active cohort of 7: ceiling(0.5 * 7) = ceiling(3.5) = 4
max_recruits_7 <- maxRecruits(recruitment, active_cohort_size = 7)
print(max_recruits_7) # 4

# For active cohort of 15: ceiling(0.5 * 15) = ceiling(7.5) = 8
max_recruits_15 <- maxRecruits(recruitment, active_cohort_size = 15)
print(max_recruits_15) # 8