v_opening

v_opening_min_dose

v_opening_min_cohorts

v_opening_min_responses

<a href="https://lifecycle.r-lib.org/articles/stages.html#experimental"><img src="figures/lifecycle-experimental.svg?package=crmPack&version=2.1.0" alt="[Experimental]"></a>
These functions are only used internally to validate the format of an input
<code>Opening</code> or inherited classes and therefore not exported.

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

v_opening function

<dl><dt>object</dt>
<dd>(<code>Opening</code>) object to validate.</dd></dl>

Arguments

<ul>
<li><code>v_opening_min_dose()</code>: validates that the <code>OpeningMinDose</code> object
contains valid <code>min_dose</code> slot.</li>
<li><code>v_opening_min_cohorts()</code>: validates that the <code>OpeningMinCohorts</code> object
contains valid <code>min_cohorts</code> slot.</li>
<li><code>v_opening_min_responses()</code>: validates that the <code>OpeningMinResponses</code> object
contains valid <code>min_responses</code> and <code>include_lower_doses</code> slots.</li>
</ul>

Functions

<a href='https://lifecycle.r-lib.org/articles/stages.html#experimental'><img src='figures/lifecycle-experimental.svg' alt='[Experimental]' /></a>
These functions are only used internally to validate the format of an input
<code>Opening</code> or inherited classes and therefore not exported.

Internal Helper Functions for Validation of Opening Objects — v_opening

<dl>

<dt>object</dt>
<dd>(<code>Opening</code>) object to validate.</dd>

</dl>

Internal Helper Functions for Validation of <code>Opening</code> Objects

v_opening: Internal Helper Functions for Validation of `Opening` Objects

Description

Usage

Value

Arguments

Functions