ArmMinDoseCondition-class

.ArmMinDoseCondition

ArmMinDoseCondition

.DefaultArmMinDoseCondition

<a href="https://lifecycle.r-lib.org/articles/stages.html#experimental"><img src="figures/lifecycle-experimental.svg?package=crmPack&version=2.2.1" alt="[Experimental]"></a>
<code>ArmMinDoseCondition</code> opens an arm when the named arm has enrolled at
least one patient at the specified minimum dose or higher.

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

ArmMinDoseCondition-class function

<dl><dt>arm_name</dt>
<dd>(<code>string</code>) see slot definition.</dd>
<dt>min_dose</dt>
<dd>(<code>numeric</code>) see slot definition.</dd></dl>

Arguments

<dl>
<dt><code>arm_name</code></dt>
<dd>(<code>string</code>) the name of the arm whose data are checked.</dd></dl>
<dt><code>min_dose</code></dt>
<dd>(<code>numeric</code>) the minimum dose that must have been reached.
For combination arms, this can be a vector of minimum doses for each agent.</dd>

Slots

<a href='https://lifecycle.r-lib.org/articles/stages.html#experimental'><img src='figures/lifecycle-experimental.svg' alt='[Experimental]' /></a>
<code>ArmMinDoseCondition</code> opens an arm when the named arm has enrolled at
least one patient at the specified minimum dose or higher.

ArmMinDoseCondition — ArmMinDoseCondition-class

<dl>

<dt>arm_name</dt>
<dd>(<code>string</code>) see slot definition.</dd>


<dt>min_dose</dt>
<dd>(<code>numeric</code>) see slot definition.</dd>

</dl>

<dl>
<dt><code>arm_name</code></dt>
<dd>(<code>string</code>) the name of the arm whose data are checked.</dd>


<dt><code>min_dose</code></dt>
<dd>(<code>numeric</code>) the minimum dose that must have been reached.
For combination arms, this can be a vector of minimum doses for each agent.</dd>


</dl>

<code>ArmMinDoseCondition</code>

ArmMinDoseCondition-class: `ArmMinDoseCondition`

Description

Usage

Arguments

Slots