HierarchicalData-class

.HierarchicalData

HierarchicalData

.DefaultHierarchicalData

<a href="https://lifecycle.r-lib.org/articles/stages.html#experimental"><img src="figures/lifecycle-experimental.svg?package=crmPack&version=2.2.1" alt="[Experimental]"></a>
<code>HierarchicalData</code> is a class for hierarchical designs,
storing the data for all arms together.

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

HierarchicalData-class function

<dl><dt>...</dt>
<dd>named <code>Data</code> objects, one for each arm in the trial.
The argument names are used as the arm names.</dd></dl>

Arguments

<dl>
<dt><code>arms</code></dt>
<dd>(<code>list</code>) a named list of <code>Data</code> objects, one
for each arm in the trial. The names of the list are the
arm names.</dd></dl>

Slots

<a href='https://lifecycle.r-lib.org/articles/stages.html#experimental'><img src='figures/lifecycle-experimental.svg' alt='[Experimental]' /></a>
<code>HierarchicalData</code> is a class for hierarchical designs,
storing the data for all arms together.

HierarchicalData — HierarchicalData-class

<dl>

<dt>...</dt>
<dd>named <code>Data</code> objects, one for each arm in the trial.
The argument names are used as the arm names.</dd>

</dl>

<dl>
<dt><code>arms</code></dt>
<dd>(<code>list</code>) a named list of <code>Data</code> objects, one
for each arm in the trial. The names of the list are the
arm names.</dd>


</dl>

<code>HierarchicalData</code>

HierarchicalData-class: `HierarchicalData`

Description

Usage

Arguments

Slots

Examples