crmPack (version 2.2.1)

IncrementsComboOneDrugOnly-class: IncrementsComboOneDrugOnly

Description

IncrementsComboOneDrugOnly is the class for increments control in combination trials when only one drug is allowed to be escalated.

Usage

IncrementsComboOneDrugOnly()
.DefaultIncrementsComboOneDrugOnly()

Details

Under this rule, when escalating drug 1 to a dose above the last administered drug 1 dose, drug 2 must remain at or below its last administered dose, and vice versa. In other words, at most one drug may be escalated in any given cohort. No parameters are required; the rule is fully defined by the "one drug only" principle.

Examples

# Create a rule that allows escalation of only one drug at a time in a
# two-drug combination trial.
my_increments <- IncrementsComboOneDrugOnly()