h_hierarchical_get_decision_samples

In a hierarchical design, the samples used for decision rules in each arm may either be the overall
samples from the hierarchical model (if borrowing is allowed)
or the arm-specific samples (if no borrowing).

internal

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

h_hierarchical_get_decision_samples function

<dl><dt>samples</dt>
<dd>the overall samples from the hierarchical model.</dd>
<dt>arm_name</dt>
<dd>the name of the arm for which we want to get the samples for decision rules.</dd>
<dt>arm</dt>
<dd>the <code>DesignArm</code> object for this arm.</dd>
<dt>arm_data</dt>
<dd>the data for this arm.</dd>
<dt>mcmcOptions</dt>
<dd>the MCMC options to use if we need to fit an arm-specific model.</dd></dl>

Arguments

Helper function to get the samples used for decision rules in a hierarchical design — h_hierarchical_get_decision_samples

<dl>

<dt>samples</dt>
<dd>the overall samples from the hierarchical model.</dd>


<dt>arm_name</dt>
<dd>the name of the arm for which we want to get the samples for decision rules.</dd>


<dt>arm</dt>
<dd>the <code>DesignArm</code> object for this arm.</dd>


<dt>arm_data</dt>
<dd>the data for this arm.</dd>


<dt>mcmcOptions</dt>
<dd>the MCMC options to use if we need to fit an arm-specific model.</dd>

</dl>

Helper function to get the samples used for decision rules in a hierarchical design

h_hierarchical_get_decision_samples: Helper function to get the samples used for decision rules in a hierarchical design

Description

Usage

Value

Arguments