h_prob_two_drugs_combo

Combines delegated single-agent toxicity probabilities with the combo
interaction term. Both the monotherapy probabilities and the interaction
covariate follow the corresponding single-agent model definitions.

internal

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

h_prob_two_drugs_combo function

<dl><dt>dose</dt>
<dd>(<code>numeric</code> or <code>matrix</code>) one or more combo dose combinations.</dd>
<dt>model</dt>
<dd>(<code>TwoDrugsCombo</code>) combo model.</dd>
<dt>samples</dt>
<dd>(<code>Samples</code>) combo model samples.</dd></dl>

Arguments

Calculate Two-Drug Combo Toxicity Probabilities — h_prob_two_drugs_combo

<dl>

<dt>dose</dt>
<dd>(<code>numeric</code> or <code>matrix</code>) one or more combo dose combinations.</dd>


<dt>model</dt>
<dd>(<code>TwoDrugsCombo</code>) combo model.</dd>


<dt>samples</dt>
<dd>(<code>Samples</code>) combo model samples.</dd>

</dl>

Calculate Two-Drug Combo Toxicity Probabilities

h_prob_two_drugs_combo: Calculate Two-Drug Combo Toxicity Probabilities

Description

Usage

Value

Arguments