h_prob_two_drugs_combo_normalized_dose

Reuses the dose-normalization expression inferred from a single-agent JAGS
data model, such as <code>x / ref_dose</code> or <code>x - ref_dose</code>, and evaluates it for R
dose inputs. The result is used for the combo interaction term so runtime
probabilities match the JAGS model used for MCMC.

internal

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

h_prob_two_drugs_combo_normalized_dose function

<dl><dt>dose</dt>
<dd>(<code>numeric</code>) single-agent doses.</dd>
<dt>single_model</dt>
<dd>(<code>GeneralModel</code>) single-agent model.</dd></dl>

Arguments

Evaluate a Single-Agent Dose Normalization — h_prob_two_drugs_combo_normalized_dose

<dl>

<dt>dose</dt>
<dd>(<code>numeric</code>) single-agent doses.</dd>


<dt>single_model</dt>
<dd>(<code>GeneralModel</code>) single-agent model.</dd>

</dl>

Evaluate a Single-Agent Dose Normalization

h_prob_two_drugs_combo_normalized_dose: Evaluate a Single-Agent Dose Normalization

Description

Usage

Value

Arguments