h_prob_two_drugs_combo_single_prob

Computes the monotherapy toxicity contribution for one drug by delegating to
that drug's own <code>prob()</code> method. This keeps the combo probability calculation
aligned with each single-agent link function and dose transformation.

internal

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

h_prob_two_drugs_combo_single_prob function

<dl><dt>dose</dt>
<dd>(<code>matrix</code>) combo dose combinations, one row per combination.</dd>
<dt>model</dt>
<dd>(<code>TwoDrugsCombo</code>) combo model.</dd>
<dt>samples</dt>
<dd>(<code>Samples</code>) combo model samples.</dd>
<dt>drug_index</dt>
<dd>(<code>integer</code>) index of the single-agent model to extract.</dd></dl>

Arguments

Evaluate Single-Agent Toxicity Probabilities in a Combo Model — h_prob_two_drugs_combo_single_prob

<dl>

<dt>dose</dt>
<dd>(<code>matrix</code>) combo dose combinations, one row per combination.</dd>


<dt>model</dt>
<dd>(<code>TwoDrugsCombo</code>) combo model.</dd>


<dt>samples</dt>
<dd>(<code>Samples</code>) combo model samples.</dd>


<dt>drug_index</dt>
<dd>(<code>integer</code>) index of the single-agent model to extract.</dd>

</dl>

Evaluate Single-Agent Toxicity Probabilities in a Combo Model

h_prob_two_drugs_combo_single_prob: Evaluate Single-Agent Toxicity Probabilities in a Combo Model

Description

Usage

Value

Arguments