h_tite_logistic_modelspecs

Build the shared JAGS data list for TITE logistic CRM models.

internal

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

h_tite_logistic_modelspecs function

<dl><dt>model</dt>
<dd>(<code>GeneralModel</code>) a logistic TITE model with <code>params</code> and
<code>ref_dose</code> slots.</dd>
<dt>weight_method</dt>
<dd>(<code>string</code>) either <code>"linear"</code> or <code>"adaptive"</code>.</dd>
<dt>nObs</dt>
<dd>(<code>integer</code>) number of observations.</dd>
<dt>u</dt>
<dd>(<code>numeric</code>) follow-up times.</dd>
<dt>Tmax</dt>
<dd>(<code>number</code>) DLT assessment window.</dd>
<dt>y</dt>
<dd>(<code>integer</code>) DLT indicators.</dd>
<dt>from_prior</dt>
<dd>(<code>flag</code>) whether prior-only specifications are
requested.</dd></dl>

Arguments

Build the shared JAGS data list for TITE logistic CRM models. — h_tite_logistic_modelspecs

<dl>

<dt>model</dt>
<dd>(<code>GeneralModel</code>) a logistic TITE model with <code>params</code> and
<code>ref_dose</code> slots.</dd>


<dt>weight_method</dt>
<dd>(<code>string</code>) either <code>"linear"</code> or <code>"adaptive"</code>.</dd>


<dt>nObs</dt>
<dd>(<code>integer</code>) number of observations.</dd>


<dt>u</dt>
<dd>(<code>numeric</code>) follow-up times.</dd>


<dt>Tmax</dt>
<dd>(<code>number</code>) DLT assessment window.</dd>


<dt>y</dt>
<dd>(<code>integer</code>) DLT indicators.</dd>


<dt>from_prior</dt>
<dd>(<code>flag</code>) whether prior-only specifications are
requested.</dd>

</dl>

Build the shared JAGS data list for TITE logistic CRM models.

h_tite_logistic_modelspecs: Build the shared JAGS data list for TITE logistic CRM models.

Description

Usage

Value

Arguments