plot,ComboSimulations,missing-method

plot-ComboSimulations-missing

<a href="https://lifecycle.r-lib.org/articles/stages.html#experimental"><img src="figures/lifecycle-experimental.svg?package=crmPack&version=2.2.1" alt="[Experimental]"></a>
Summarize two-drug combination simulations with plots.
This plot method can be applied to <code>ComboSimulations</code> objects. Possible
<code>type</code>s of plots are:<dl>
<dt>trajectory</dt>
<dd>Summary of simulated dose trajectories for each drug</dd><dt>dosesTried</dt>
<dd>Average proportions of tested doses for each drug</dd><dt>trajectory2D</dt>
<dd>2D dose-plane evolution with arrows for dose transitions,
and labels showing DLTs/patients plus a step index hint</dd>
</dl>

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

plot,ComboSimulations,missing-method function

<dl><dt>x</dt>
<dd>(<code>ComboSimulations</code>) the object we want to plot from.</dd>
<dt>y</dt>
<dd>(<code>missing</code>) not used.</dd>
<dt>type</dt>
<dd>(<code>character</code>) the type of plots you want to obtain.</dd>
<dt>...</dt>
<dd>not used.</dd></dl>

Arguments

<a href='https://lifecycle.r-lib.org/articles/stages.html#experimental'><img src='figures/lifecycle-experimental.svg' alt='[Experimental]' /></a>
Summarize two-drug combination simulations with plots.
This plot method can be applied to <code>ComboSimulations</code> objects. Possible
<code>type</code>s of plots are:<dl>
<dt>trajectory</dt>
<dd>Summary of simulated dose trajectories for each drug</dd>

<dt>dosesTried</dt>
<dd>Average proportions of tested doses for each drug</dd>

<dt>trajectory2D</dt>
<dd>2D dose-plane evolution with arrows for dose transitions,
and labels showing DLTs/patients plus a step index hint</dd>


</dl>

Plot ComboSimulations — plot,ComboSimulations,missing-method

<dl>

<dt>x</dt>
<dd>(<code>ComboSimulations</code>) the object we want to plot from.</dd>


<dt>y</dt>
<dd>(<code>missing</code>) not used.</dd>


<dt>type</dt>
<dd>(<code>character</code>) the type of plots you want to obtain.</dd>


<dt>...</dt>
<dd>not used.</dd>

</dl>

Plot <code>ComboSimulations</code>

plot,ComboSimulations,missing-method: Plot `ComboSimulations`

Description

Usage

Value

Arguments