plot,HierarchicalSamples,HierarchicalModel-method

Plotting hierarchical dose-toxicity model fits

Implements a wide range of dose escalation
designs. The focus is on model-based designs, ranging from classical and
modern continual reassessment methods (CRMs) based on dose-limiting toxicity
endpoints to dual-endpoint designs taking into account a biomarker/efficacy
outcome. Bayesian inference is performed via MCMC sampling in JAGS, and it is easy
to setup a new design with custom JAGS code. However, it is also possible to
implement 3+3 designs for comparison or models with non-Bayesian estimation.
The whole package is written in a modular form in the S4 class system, making it
very flexible for adaptation to new models, escalation or stopping rules.
Further details are presented in
Sabanés Bové et al. (2019) <doi:10.18637/jss.v089.i10>.

Daniel Sabanes Bove

crmPack

Object-Oriented Implementation of Dose Escalation Designs

Daniel Sabanés Bové

Wai Yin Yeung

Burak Kuersad Guenhan

Giuseppe Palermo

Thomas Jaki

Jiawen Zhu

Ziwei Liao

Dimitris Kontos

Marlene Schulte-Goebel

Doug Kelkhoff

Oliver Boix

Robert Adams

Clara Beck

John Kirkpatrick

Wojciech Wójciak

Guanya Peng

Prerana Chandratre

F. Hoffmann-La Roche AG 

Merck Healthcare KGaA 

Bayer AG 

RPACT GmbH 

plot,HierarchicalSamples,HierarchicalModel-method function

<dl><dt>x</dt>
<dd>the HierarchicalSamples object.</dd>
<dt>y</dt>
<dd>the HierarchicalModel object.</dd>
<dt>data</dt>
<dd>the HierarchicalData object.</dd>
<dt>ncol</dt>
<dd>(<code>count</code> or <code>NULL</code>) number of columns in the combined plot.
If <code>NULL</code>, a compact layout is chosen automatically.</dd>
<dt>...</dt>
<dd>passed to the arm-specific <code>plot</code> methods.</dd></dl>

Arguments

Plotting hierarchical dose-toxicity model fits — plot,HierarchicalSamples,HierarchicalModel-method

<dl>

<dt>x</dt>
<dd>the HierarchicalSamples object.</dd>


<dt>y</dt>
<dd>the HierarchicalModel object.</dd>


<dt>data</dt>
<dd>the HierarchicalData object.</dd>


<dt>ncol</dt>
<dd>(<code>count</code> or <code>NULL</code>) number of columns in the combined plot.
If <code>NULL</code>, a compact layout is chosen automatically.</dd>


<dt>...</dt>
<dd>passed to the arm-specific <code>plot</code> methods.</dd>

</dl>

Plotting hierarchical dose-toxicity model fits

plot,HierarchicalSamples,HierarchicalModel-method: Plotting hierarchical dose-toxicity model fits

Description

Usage

Value

Arguments