ctrdata (version 1.16.0)

ctrLoadQueryIntoDb: Load and store register trial information

Description

Retrieves information on clinical trials from registers and stores it in a collection in a database. Main function of ctrdata for accessing registers. A collection can store trial information from different queries or different registers. Query details are stored in the collection and can be accessed using dbQueryHistory. A previous query can be re-run, which replaces or adds trial records while keeping any user annotations of trial records.

Usage

ctrLoadQueryIntoDb(
  queryterm = NULL,
  register = "",
  querytoupdate = NULL,
  forcetoupdate = FALSE,
  euctrresults = FALSE,
  euctrresultshistory = FALSE,
  documents.path = NULL,
  documents.regexp = "prot|sample|statist|sap_|p1ar|p2ars|ctalett|lay|^[0-9]+ ",
  annotation.text = "",
  annotation.mode = "append",
  only.count = FALSE,
  con = NULL,
  verbose = FALSE,
  ...
)

Value

A list with elements `n` (number of trial records newly imported or updated), `success` (a vector of _id's of successfully loaded records), `failed` (a vector of identifiers of records that failed to load) and `queryterm` (the query term used). The returned list has several attributes (including database and collection name, as well as the query history of this database collection) to facilitate documentation.

Arguments

queryterm

Either a string with the full URL of a search query in a register, or the data frame returned by the ctrGetQueryUrl or the dbQueryHistory functions, or, together with parameter register, a string with query elements of a search URL. The query details are recorded in the collection for later use to update records. For "CTIS", queryterm can be an empty string to obtain all trial records. For automatically copying the user's query of a register in a web browser to the clipboard, see here

register

String with abbreviation of register to query, either "EUCTR", "CTGOV", "ISRCTN" or "CTIS". Not needed if queryterm provides a full URL to query results.

querytoupdate

Either the word "last", or the row number of a query in the data frame returned by dbQueryHistory that should be run to retrieve any new or update trial records since this query was run the last time. This parameter takes precedence over queryterm. For "EUCTR", updates are available only for the last seven days; the query is run again if more time has passed since it was run last. Does not work with "CTIS" at this time.

forcetoupdate

If TRUE, run again the query given in querytoupdate, irrespective of when it was run last. Default is FALSE.

euctrresults

If TRUE, also download available results when retrieving and loading trials from EUCTR. This slows down this function. (For "CTGOV", "CTGOV2" and "CTIS", all available results are always retrieved and loaded into the collection.)

euctrresultshistory

If TRUE, also download available history of results publication in "EUCTR." This is quite time-consuming. Default is FALSE.

documents.path

If this is a relative or absolute path to a directory that exists or can be created, save any documents into it that are directly available from the register ("EUCTR", "CTGOV", "CTGOV2", "ISRCTN", "CTIS") such as PDFs on results, analysis plans, spreadsheets, patient information sheets, assessments or product information. Default is NULL, which disables saving documents.

documents.regexp

Regular expression, case insensitive, to select documents, if saving documents is requested (see documents.path). If set to NULL, empty placeholder files are saved for every document that could be saved. Default is "prot|sample|statist|sap_|p1ar|p2ars|ctalett|lay|^[0-9]+ ". Used with "CTGOV", "CTGOV2", "ISRCTN" and "CTIS" (but not "EUCTR", for which all available documents are saved in any case).

annotation.text

Text to be including into the field "annotation" in the records retrieved with the query that is to be loaded into the collection. The contents of the field "annotation" for a trial record are preserved e.g. when running this function again and loading a record of a with an annotation, see parameter annotation.mode.

annotation.mode

One of "append" (default), "prepend" or "replace" for new annotation.text with respect to any existing annotation for the records retrieved with the query that is to be loaded into the collection.

only.count

Set to TRUE to return only the number of trial records found in the register for the query. Does not load trial information into the database. Default is FALSE.

con

A connection object, see section `Databases` in ctrdata.

verbose

Printing additional information if set to TRUE; default is FALSE.

...

Do not use (capture deprecated parameters).

Examples

if (FALSE) {

dbc <- nodbi::src_sqlite(collection = "my_collection")

# Retrieve protocol- and results-related information
# on two specific trials identified by their EU number
ctrLoadQueryIntoDb(
  queryterm = "2005-001267-63+OR+2008-003606-33",
  register = "EUCTR",
  euctrresults = TRUE,
  con = dbc
)

# Retrieve all information on about 2,000 ongoing
# interventional cancer trials involving children
# into the same collection as used before
ctrLoadQueryIntoDb(
  queryterm = "cancer&recr=Open&type=Intr&age=0",
  register = "CTGOV",
  con = dbc
)

# Retrieve all information on more than 40 trials
# that are labelled as phase 3 and that mention
# either neuroblastoma or lymphoma from ISRCTN,
# into the same collection as used before
ctrLoadQueryIntoDb(
  queryterm = paste0(
    "https://www.isrctn.com/search?",
    "q=neuroblastoma+OR+lymphoma&filters=phase%3APhase+III"),
  con = dbc
)

# Retrieve all information on completed trials in CTIS
ctrLoadQueryIntoDb(
  queryterm = "https://euclinicaltrials.eu/app/#/search?status=Ended",
  con = dbc
)
}