f.likelyPlatformTrial

Trial concept calculated: platform trial, research platform.
As operational definition, at least one of these criteria is true:
a. trial has "platform", "basket", "umbrella", "multi.?arm", "multi.?stage"
or "master protocol" in its title or description (for ISRCTN, this is the
only criterion; some trials in EUCTR lack data in English),
b. trial has more than 2 active arms with different investigational medicines,
after excluding comparator, auxiliary and placebo medicines (calculated with
f.numTestArmsSubstances; not used for ISRCTN because it cannot be
calculated precisely),
c. trial more than 2 periods, after excluding safety run-in, screening,
enrolling, extension and follow-up periods (for CTGOV and CTGOV2, this
criterion requires results-related data).
Requires that EUCTR results have been included in the collection, using
ctrLoadQueryIntoDb(queryterm = ..., euctrresults = TRUE, con = ...).
Requires packages dplyr and stringdist to be installed; stringdist is used
for evaluating terms in brackets in the trial title, where trials may be
related if the term similarity is 0.7 or higher.

A system for querying, retrieving and analyzing
protocol- and results-related information on clinical trials from
four public registers, the 'European Union Clinical Trials Register'
('EUCTR', <https://www.clinicaltrialsregister.eu/>),
'ClinicalTrials.gov' (<https://clinicaltrials.gov/> and also
translating queries the retired classic interface), the
'ISRCTN' (<http://www.isrctn.com/>) and the
'European Union Clinical Trials Information System'
('CTIS', <https://euclinicaltrials.eu/>).
Trial information is downloaded, converted and stored in a database
('PostgreSQL', 'SQLite', 'DuckDB' or 'MongoDB'; via package 'nodbi').
Protocols, statistical analysis plans, informed consent sheets and other
documents in registers associated with trials can also be downloaded.
Other functions implement trial concepts canonically across registers,
identify deduplicated records, easily find and extract variables
(fields) of interest even from complex nested data as used by the
registers, merge variables and update queries.
The package can be used for monitoring, meta- and trend-analysis of
the design and conduct as well as of the results of clinical trials
across registers.

Ralf Herold

ctrdata

Retrieve and Analyze Clinical Trials Data from Public Registers

f.likelyPlatformTrial function

<dl><dt>df</dt>
<dd>data frame such as from dbGetFieldsIntoDf. If `NULL`,
prints fields needed in `df` for calculating this trial concept, which can
be used with dbGetFieldsIntoDf.</dd></dl>

Arguments

Calculate if study is likely a platform trial or not — f.likelyPlatformTrial

<dl>

<dt>df</dt>
<dd>data frame such as from dbGetFieldsIntoDf. If `NULL`,
prints fields needed in `df` for calculating this trial concept, which can
be used with dbGetFieldsIntoDf.</dd>

</dl>

f.likelyPlatformTrial: Calculate if study is likely a platform trial or not

Description

Usage

Value

Arguments

Details

Examples