findNSCdesigns

This function finds admissible design realisations for single-arm binary outcome trials, using non-stochastic curtailment.
The output is a data frame of admissible design realisations.

Finds single- and two-arm designs using stochastic curtailment, as described by Law et al. (2022) <doi:10.1080/10543406.2021.2009498> and Law et al. (2021) <doi:10.1002/pst.2067> respectively. Designs can be single-stage or multi-stage. Non-stochastic curtailment is possible as a special case. Desired error-rates, maximum sample size and lower and upper anticipated response rates are inputted and suitable designs are returned with operating characteristics. Stopping boundaries and visualisations are also available. The package can find designs using other approaches, for example designs by Simon (1989) <doi:10.1016/0197-2456(89)90015-9> and Mander and Thompson (2010) <doi:10.1016/j.cct.2010.07.008>. Other features: compare and visualise designs using a weighted sum of expected sample sizes under the null and alternative hypotheses and maximum sample size; visualise any binary outcome design.

Martin Law

curtailment

Finds Binary Outcome Designs Using Stochastic Curtailment

findNSCdesigns function

<dl><dt>nmin</dt>
<dd>Minimum permitted sample size.</dd>
<dt>nmax</dt>
<dd>Maximum permitted sample size.</dd>
<dt>p0</dt>
<dd>Probability for which to control the type-I error-rate</dd>
<dt>p1</dt>
<dd>Probability for which to control the power</dd>
<dt>alpha</dt>
<dd>Significance level</dd>
<dt>power</dt>
<dd>Required power (1-beta).</dd>
<dt>progressBar</dt>
<dd>Logical. If TRUE, shows progress bar. Defaults to FALSE.</dd></dl>

Arguments

findNSCdesigns — findNSCdesigns

<dl>

<dt>nmin</dt>
<dd>Minimum permitted sample size.</dd>


<dt>nmax</dt>
<dd>Maximum permitted sample size.</dd>


<dt>p0</dt>
<dd>Probability for which to control the type-I error-rate</dd>


<dt>p1</dt>
<dd>Probability for which to control the power</dd>


<dt>alpha</dt>
<dd>Significance level</dd>


<dt>power</dt>
<dd>Required power (1-beta).</dd>


<dt>progressBar</dt>
<dd>Logical. If TRUE, shows progress bar. Defaults to FALSE.</dd>

</dl>

findNSCdesigns: findNSCdesigns

Description

Usage

Value

Arguments

Examples