cusum (version 0.4.1)

racusum_limit_sim: Simulate control limit given false signal probability alpha for RA-CUSUM charts

Description

False-signal-probability-simulation of Control Limits h for risk-adjusted CUSUM charts

Usage

racusum_limit_sim(patient_risks, odds_multiplier, n_simulation, alpha,
  seed = NULL)

Arguments

patient_risks

Double. Vector of patient risk scores (individual risk of adverse event)

odds_multiplier

Double. Odds multiplier of adverse event under the alternative hypothesis (<1 looks for decreases)

n_simulation

Integer. Number of simulation runs

alpha

Double. False signal probability of RA-CUSUM

seed

Integer. Seed for RNG

Value

Returns the control limit for signalling performance change (double)

Examples

# NOT RUN {
# Patients risks are usually known from Phase I.
# If not, these risk scores can be simulated.

# define possible patient risk scores
risks <- c(0.001, 0.01, 0.1, 0.002, 0.02, 0.2)

# sample risk population of size n = 100
set.seed(2046)
patient_risks <- sample(x = risks, size = 100, replace = TRUE)

# simulate control limits for alpha = 0.05
racusum_limit_sim(patient_risks,
  odds_multiplier = 2,
  n_simulation = 1000,
  alpha = 0.05,
  seed = 2046
)
# }