datasets (version 3.2.5)

Indometh: Pharmacokinetics of Indomethacin

Description

The Indometh data frame has 66 rows and 3 columns of data on the pharmacokinetics of indometacin (or, older spelling, ‘indomethacin’).

Usage

Indometh

Format

An object of class c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame") containing the following columns:

Subject

an ordered factor with containing the subject codes. The ordering is according to increasing maximum response.

time

a numeric vector of times at which blood samples were drawn (hr).

conc

a numeric vector of plasma concentrations of indometacin (mcg/ml).

Source

Kwan, Breault, Umbenhauer, McMahon and Duggan (1976) Kinetics of Indomethacin absorption, elimination, and enterohepatic circulation in man. Journal of Pharmacokinetics and Biopharmaceutics 4, 255--280. Davidian, M. and Giltinan, D. M. (1995) Nonlinear Models for Repeated Measurement Data, Chapman & Hall (section 5.2.4, p.\ifelse{latex}{\out{~}}{ } 129) Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer.

Details

Each of the six subjects were given an intravenous injection of indometacin.

This dataset was originally part of package nlme, and that has methods (including for [, as.data.frame, plot and print) for its grouped-data classes.

See Also

SSbiexp for models fitted to this dataset.