# Indometh

##### Pharmacokinetics of Indomethacin

The `Indometh`

data frame has 66 rows and 3 columns of data on
the pharmacokinetics of indometacin (or, older spelling,
‘indomethacin’).

- Keywords
- datasets

##### Usage

`Indometh`

##### Details

Each of the six subjects were given an intravenous injection of indometacin.

This dataset was originally part of package `nlme`

, and that has
methods (including for `[`

, `as.data.frame`

, `plot`

and
`print`

) for its grouped-data classes.

##### Format

An object of class
`c("nfnGroupedData", "nfGroupedData", "groupedData", "data.frame")`

containing the following columns:

- Subject
- an ordered factor with containing the subject codes. The ordering is according to increasing maximum response.
- time
- a numeric vector of times at which blood samples were drawn (hr).
- conc
- a numeric vector of plasma concentrations of indometacin (mcg/ml).

##### Source

Kwan, Breault, Umbenhauer, McMahon and Duggan (1976)
Kinetics of Indomethacin absorption, elimination, and
enterohepatic circulation in man.
*Journal of Pharmacokinetics and Biopharmaceutics* **4**,
255--280. Davidian, M. and Giltinan, D. M. (1995)
*Nonlinear Models for Repeated Measurement Data*,
Chapman & Hall (section 5.2.4, p.\ifelse{latex}{\out{~}}{ } 129) Pinheiro, J. C. and Bates, D. M. (2000) *Mixed-effects Models in
S and S-PLUS*, Springer.

##### See Also

`SSbiexp`

for models fitted to this dataset.

*Documentation reproduced from package datasets, version 3.3.0, License: Part of R 3.3.0*