PermuteMultiHits

Total number of de novo variants observed in dataset

Number of genes with >1 de novo variant (of class "class") in the population

nperms

class

Gene identifier used. One of "hgncID", "hgncSymbol",
"enstID", "ensgID" or "geneName" (default, equals ensembl "external_gene_name")

geneId

Genes to include in analysis. "all" or a vector of gene
names.

includeGenes

Probability table. A user-defined table of probabilities can
be provided here, to replace the probability table included in the package.

probTable


An internal function called by denovolyzeMultiHits


An integrated toolset for the analysis of de novo (sporadic)
genetic sequence variants. denovolyzeR implements a mutational model that
estimates the probability of a de novo genetic variant arising in each human
gene, from which one can infer the expected number of de novo variants in a
given population size. Observed variant frequencies can then be compared against
expectation in a Poisson framework. denovolyzeR provides a suite of functions
to implement these analyses for the interpretation of de novo variation in human
disease.

PermuteMultiHits: Permutes x variants across a genelist, and counts genes with multiple hits

Description

Usage

Arguments

Value

See Also