dfmta-package: Phase I/II Adaptive Dose-Finding Design for Combination Studies
Description
This package provides functions to run simulations and to determine the MTD
combination in on-going trials in the cases of (1) combination of two
cytotoxic agents, and (2) combination of a molecularly targeted agent with a
cytotoxic agent.Details
ll{
Package: dfmta
Type: Package
Version: 1.0
Date: 2014-10-02
License: GPL-3
}References
Riviere, MK, Yuan, Y, Dubois, F, Zohar, S (2014). A Bayesian dose-finding design for drug combination clinical trials based on the logistic model. Pharm Stat, 13, 4:247-57.
Riviere, MK, Yuan, Y, Dubois, F, Zohar, S (2014). A Bayesian dose finding design for clinical trials combining a cytotoxic agent with a molecularly targeted agent. JRSS-C.