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dfcomb (version 2.0-2)

Phase I/II Adaptive Dose-Finding Design for Combination Studies

Description

Phase I/II adaptive dose-finding design for combination studies. Several methods are proposed depending on the type of combinations: (1) the combination of two cytotoxic agents, and (2) combination of a molecularly targeted agent with a cytotoxic agent.

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Version

Install

install.packages('dfcomb')

Monthly Downloads

212

Version

2.0-2

License

GPL-3

Maintainer

Marie-Karelle Riviere

Last Published

January 24th, 2015

Functions in dfcomb (2.0-2)

CombIncrease_next

Combination determination with logistic model
CombPlateau_sim

Combination design Simulator for the combination of two agents where toxicity is increasing with the dose of both agent and efficacy is increasing and possibly plateaus with the dose of one agent
CombIncrease_sim

Combination design Simulator using Logistic model
CombPlateau_next

Combination determination for the combination of two agents where toxicity is increasing with the dose of both agent and efficacy is increasing and possibly plateaus with the dose of one agent
dfcomb-package

Phase I and Phase I/II Adaptive Dose-Finding Design for Combination Studies