dfped (version 1.1)

fuCh: Unbound fraction of the molecule in the plasma for children.

Description

Unbound fraction of the molecule in the plasma for children.

Usage

fuCh(age, fuAd, percAlb, percAlpha1AG)

Arguments

age

The age of children.

fuAd

Unbound fraction of the molecule in adults.

percAlb

Percentage of the molecule binding with albumin.

percAlpha1AG

Percentage of the molecule binding with alpha1-acid glycoprotein.

References

Petit, C., et al, (2016) Unified approach for extrapolation and bridging of adult information in early phase dose-finding paediatric studies, Statistical Methods in Medical Research, <doi:10.1177/0962280216671348>.

Johnson T., Rostami-Hodjegan A. and Tucker G. (2006) Prediction of clearance of eleven drugs and associated variability in neonates, infants and children, Clin. Pharmacokinet., 45:931-956.

See Also

Clch.Mat

Examples

# NOT RUN {
    ########
    # Note: For this example we are using a paediatric database that we have including data of 
    # children from 0 to 19 years old.
    ########

    children <- read.csv("/Users/artemistoumazi/paediatric_data_p3m/children_0_19.csv")
    AGE <- children$Age
    fu_ad <- 1
    perc_alb <- 1
    perc_alpha1AG <- 0 

    fuCh(AGE, fu_ad, perc_alb, perc_alpha1AG)
# }