dfpk (version 2.0.0)

AUC_estim: Estimation of the area under the curve, AUC.

Description

In the field of pharmacokinetics, the area under the curve (AUC) is the area under the curve (mathematically known as definite integral) in a plot of concentration of drug in blood plasma against time. AUC is computed as the doses over the second pharmacokinetic's parameter, the clearance (CL).

Usage

AUC_estim(t, conc, dose)

Arguments

t

A vector of the sampling time.

conc

The concentration of the drug in blood plasma.

dose

A vector of dose levels assigned to patients.

References

Ursino, M., et al, (2016) Dose-finding methods using pharmacokinetics in small populations (under review).

See Also

pk.estim, nsim

Examples

dose = c(12.59972,34.65492,44.69007,60.80685,83.68946,100.37111)
conc = c(20,30,40,50,60,70)
t = seq(0,24,length.out=48)
auc_estimation <- AUC_estim(t,conc,dose)	
auc_estimation