dosefinding-class

An S4 class to represent a dosefinding results.

Statistical methods involving PK measures are provided, in the dose allocation
process during a Phase I clinical trials. These methods enter pharmacokinetics
(PK) in the dose finding designs in different ways, including covariates models,
dependent variable or hierarchical models.
This package provides functions to generate data from several scenarios and functions
to run simulations which their objective is to determine the maximum tolerated dose (MTD).

Artemis Toumazi

dfpk

Bayesian Dose-Finding Designs using Pharmacokinetics(PK) for
Phase I Clinical Trials

dosefinding-class function

<dl class="dl-horizontal">
<dt><code>pid</code></dt><dd>Patient's ID provided in the study.</dd></dl><dt><code>N</code></dt><dd>The total number of patients.</dd><dt><code>time</code></dt><dd>The time sampling.</dd><dt><code>doses</code></dt><dd>The dose levels of the drug.</dd><dt><code>conc</code></dt><dd>Concentration of the drug.</dd><dt><code>p0</code></dt><dd>The skeleton of CRM.</dd><dt><code>L</code></dt><dd>A threshold set before starting the trial.</dd><dt><code>nchains</code></dt><dd>Number of chains for the stan model.</dd><dt><code>niter</code></dt><dd>Number of iterations for the stan model.</dd><dt><code>nadapt</code></dt><dd>Number of warmup iterations for the stan model.</dd><dt><code>newDose</code></dt><dd>The next maximum tolerated dose (MTD) if TR=1 else the selected percentage of MTD.</dd><dt><code>MTD</code></dt><dd>The vector containing all the maximum tolerated dose for each TR.</dd><dt><code>MtD</code></dt><dd>The next maximum tolerated dose (MTD).</dd><dt><code>theta</code></dt><dd>The toxicity (probability) target.</dd><dt><code>doseLevels</code></dt><dd>A vector of dose levels assigned to patients in the trial.</dd><dt><code>toxicity</code></dt><dd>The toxicity outcome.</dd><dt><code>AUCs</code></dt><dd>A vector with the computed AUC values of each patient.</dd><dt><code>TR</code></dt><dd>The number of replicates clinical trials.</dd><dt><code>preal</code></dt><dd>The real probability of toxicity.</dd><dt><code>pstim</code></dt><dd>The estimated mean probabilities of toxicity.</dd><dt><code>pstimQ1</code></dt><dd>The 1st quartile of estimated probability of toxicity.</dd><dt><code>pstimQ3</code></dt><dd>The 3rd quartile of estimated probability of toxicity.</dd><dt><code>model</code></dt><dd>A character string to specify the working model used in the method.</dd>

dosefinding-class: An S4 class to represent a dosefinding results.

Description

Arguments

Slots