biasAdjust: baisAdjust performs bias adjustment of normalized data
Description
biasAdjust takes a normalized dataset and applies a multiplicative
scalar derived from the data to help account for expression biases.
These expression biases can come from many sources including dye
bias,hybridization efficacy,changes in personnel,etc.After bias
adjustment the data is ready for differential gene analysis.
Usage
biasAdjust(normalized, numSlides)
Arguments
normalized
normalized is a matrix of normalized microarray
data.The first row consists of headers ans the first column
consists of gene names.
numSlides
numSlides is the total number of chips of the
microarray dataset.
Value
Returns a matrix of bias adjusted normalized data.
References
Dozmorov I,Centola,M. An associative analysis of gene expression array data.
Bioinformatics.2003 Jan22;19(2):204-11
Knowlton N,Dozmorov I, Centola M. Microarray data Analysis Tool box(MDAT):
for normalization,adjustment and analysis of gene expression data.
Bioonformatics.2004 Dec 12;20(18):3687-90