dataTrim: DataTrim using pseudo winsorization algorithm
Description
DataTrim cleans the data through a pseudo winsorization algorithm.
First, the mean and SD are calculated. Then, any values above 2SD
are trimmed.The mean is recalculated and any values less then 2 SD
are trimmed.This process of cutting 2 SD above the mean and then
2 SD below the mean is repeated until no further cuts are possible.
Usage
dataTrim(chipdata)
Arguments
chipdata
chipdata is a vector of chipdata from microarray
chips.
Value
Returns a vector of trimmed chipdata representing background
based on pseudo winsorization algorithm.
References
Dozmorov I,Centola,M. An associative analysis of gene expression array data.
Bioinformatics.2003 Jan22;19(2):204-11
Knowlton N,Dozmorov I, Centola M. Microarray data Analysis Tool box(MDAT):
for normalization,adjustment and analysis of gene expression data.
Bioonformatics.2004 Dec 12;20(18):3687-90