diffeRenTES (version 0.3.2)
Computation of TES-Based Cell Differentiation Trees
Description
Computes the ATM (Attractor Transition Matrix) structure and
the tree-like structure describing the cell differentiation process
(based on the Threshold Ergodic Set concept introduced by Serra and
Villani), starting from the Boolean networks with synchronous updating
scheme of the 'BoolNet' R package. TESs (Threshold Ergodic Sets) are
the mathematical abstractions that represent the different cell types
arising during ontogenesis. TESs and the powerful model of biological
differentiation based on Boolean networks to which it belongs have
been firstly described in "A Dynamical Model of Genetic Networks for
Cell Differentiation" Villani M, Barbieri A, Serra R (2011) A
Dynamical Model of Genetic Networks for Cell Differentiation. PLOS ONE
6(3): e17703.