reml

Restricted maximum likelihood estimate of DOOR outcome cell proportions

internal

Statistical methods and related graphical representations for the Desirability of Outcome Ranking (DOOR) methodology. The DOOR is a paradigm for the design, analysis, interpretation of clinical trials and other research studies based on the patient centric benefit risk evaluation. The package provides functions for generating summary statistics from individual level/summary level datasets, conduct DOOR probability-based inference, and visualization of the results. For more details of DOOR methodology, see Hamasaki and Evans (2025) <doi:10.1201/9781003390855>. For more explanation of the statistical methods and the graphics, see the technical document and user manual of the DOOR 'Shiny' apps at <https://methods.bsc.gwu.edu>.

Yijie He

door

Analysis of Clinical Trials with the Desirability of Outcome
Ranking Methodology

Qihang Wu

Toshimitsu Hamasaki

reml function

<dl><dt>y1, y2</dt>
<dd>vector of frequency distribution of DOOR outcome for group 1, 2</dd>
<dt>theta.null</dt>
<dd>The DOOR probability of interest</dd></dl>

Arguments

Restricted maximum likelihood estimate of DOOR outcome cell proportions — reml

<dl>

<dt>y1, y2</dt>
<dd>vector of frequency distribution of DOOR outcome for group 1, 2</dd>


<dt>theta.null</dt>
<dd>The DOOR probability of interest</dd>

</dl>

reml: Restricted maximum likelihood estimate of DOOR outcome cell proportions

Description

Usage

Value

Arguments