MeanResponse

MeanResponse.dr4pl

MeanResponse.numeric

MeanResponse.dr4pl_theta

MeanResponse.dr4pl_log10

arguments to be passed to S3 methods

dr4pl

Parameters of the dr4pl object. Usually made with [dr4pl_theta]

theta

domain values for 4PL model. Values
should always be passed to this function on the
linear space.

Compute an estimated mean response.

Models the relationship between dose levels and responses in a pharmacological experiment using the 4 Parameter Logistic model. Traditional packages on dose-response modelling such as 'drc' and 'nplr' often draw errors due to convergence failure especially when data have outliers or non-logistic shapes. This package provides robust estimation methods that are less affected by outliers and other initialization methods that work well for data lacking logistic shapes. We provide the bounds on the parameters of the 4PL model that prevent parameter estimates from diverging or converging to zero and base their justification in a statistical principle. These methods are used as remedies to convergence failure problems. Gadagkar, S. R. and Call, G. B. (2015) <doi:10.1016/j.vascn.2014.08.006> Ritz, C. and Baty, F. and Streibig, J. C. and Gerhard, D. (2015) <doi:10.1371/journal.pone.0146021>.

MeanResponse: Compute an estimated mean response.

Description

Usage

Arguments

Value