checkerboardData

A dataset containing data from 10 different in-vitro drug combination 
experiments for an antiviral treatment (compound 1) using a checkerboard 
design. The variables are as follows:

Perform assessment of synergy/antagonism for drug combinations based
on the Loewe additivity model, following Harbron's approach (Statistics in
Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling
of the drug interaction index and supports "2-stage" estimation in addition
to "1-stage" estimation, including bootstrap-based confidence intervals.
The method requires data on the monotherapy responses and the package
accommodates both checkerboard and ray designs. Functions are available for
graphical exploration of model goodness-of-fit and diagnostics, as well as
for synergy/antagonism assessment in 2D and 3D.

Maxim Nazarov

drugCombo

Drug Interaction Modeling Based on Loewe Additivity Following
Harbron's Approach

checkerboardData function

A data frame with 9360 observations of 5 variables:<ul>
<li>d1: dose of the first compound</li>
<li>d2: dose of the second compound</li>
<li>effect: observed effect (normalized cell counts)</li>
<li>plate: plate ID (1 to 3 within experiment)</li>
<li>exp: experiment ID (1 to 10)</li>
</ul>

checkerboardData: Example checkerboard design drug combination data

Description

Arguments

Format