contour.tauSurface

A <code>tauSurface</code> object returned by <code><a rd-options="" href="/link/getTauSurface?package=drugCombo&version=1.2.1" data-mini-rdoc="drugCombo::getTauSurface">getTauSurface</a></code>.

Number of digits used in <code><a rd-options="base" href="/link/format?package=drugCombo&version=1.2.1&to=base" data-mini-rdoc="base::format">format</a></code> for the 
dose labels.

digits

Further parameters, currently not used.

Contour-plot method for "tauSurface" objects

Perform assessment of synergy/antagonism for drug combinations based
on the Loewe additivity model, following Harbron's approach (Statistics in
Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling
of the drug interaction index and supports "2-stage" estimation in addition
to "1-stage" estimation, including bootstrap-based confidence intervals.
The method requires data on the monotherapy responses and the package
accommodates both checkerboard and ray designs. Functions are available for
graphical exploration of model goodness-of-fit and diagnostics, as well as
for synergy/antagonism assessment in 2D and 3D.

Maxim Nazarov

drugCombo

Drug Interaction Modeling Based on Loewe Additivity Following
Harbron's Approach

contour.tauSurface function

A <code>tauSurface</code> object returned by <code><a rd-options='' href='getTauSurface'>getTauSurface</a></code>.

Number of digits used in <code><a rd-options='base' href='format'>format</a></code> for the 
dose labels.

contour.tauSurface: Contour-plot method for "tauSurface" objects

Description

Usage

Arguments

Value

Details