fitPlot2d

A <code>HarbronFit</code> object returned by <code><a rd-options="" href="/link/fitModel?package=drugCombo&version=1.2.1" data-mini-rdoc="drugCombo::fitModel">fitModel</a></code>.

An optional <code>HarbronFit</code> object returned by 
<code><a rd-options="" href="/link/fitModel?package=drugCombo&version=1.2.1" data-mini-rdoc="drugCombo::fitModel">fitModel</a></code>. If provided, a 2d-plot comparing two model fits is 
produced. Note that the two models should have been fitted on the same data. 
Note that this argument can also be used as <code>side</code>.

fit2

Which side ("d1", "d2" or "total" for the sum of d1 and d2) to 
use as x-axis.

side

Whether to use fine grid for plotting fitted curves 
(default), or calculate predictions only at the observed data points.

useFineGrid

Model names to use for the plot legend in the case of model 
comparison (i.e. when <code>fit2</code> is provided).

modelNames

Plot 2d surface (slices) of observations and model fit

Perform assessment of synergy/antagonism for drug combinations based
on the Loewe additivity model, following Harbron's approach (Statistics in
Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling
of the drug interaction index and supports "2-stage" estimation in addition
to "1-stage" estimation, including bootstrap-based confidence intervals.
The method requires data on the monotherapy responses and the package
accommodates both checkerboard and ray designs. Functions are available for
graphical exploration of model goodness-of-fit and diagnostics, as well as
for synergy/antagonism assessment in 2D and 3D.

Maxim Nazarov

drugCombo

Drug Interaction Modeling Based on Loewe Additivity Following
Harbron's Approach

fitPlot2d function

A <code>HarbronFit</code> object returned by <code><a rd-options='' href='fitModel'>fitModel</a></code>.

An optional <code>HarbronFit</code> object returned by 
<code><a rd-options='' href='fitModel'>fitModel</a></code>. If provided, a 2d-plot comparing two model fits is 
produced. Note that the two models should have been fitted on the same data. 
Note that this argument can also be used as <code>side</code>.

fitPlot2d: Plot 2d surface (slices) of observations and model fit

Description

Usage

Arguments

Value