fitPlot3d

A <code>HarbronFit</code> object returned by 
<code><a rd-options="" href="/link/fitModel?package=drugCombo&version=1.2.1" data-mini-rdoc="drugCombo::fitModel">fitModel</a></code>.

Whether to use log-scale for x and y axes.

logScale

Whether to use fine grid for plotting the fitted surface 
(default), or calculate predictions only at the observed data points.

useFineGrid

Whether to show 'mesh' on the plot. Note: currently doesn't 
play nicely with the <code>useFineGrid</code> argument, so the latter is ignored.

showMesh

Whether to return a "htmlwidget" object instead of plotting on 
a 3d device.

widget

Plot 3d surface of observations and model fit

Perform assessment of synergy/antagonism for drug combinations based
on the Loewe additivity model, following Harbron's approach (Statistics in
Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling
of the drug interaction index and supports "2-stage" estimation in addition
to "1-stage" estimation, including bootstrap-based confidence intervals.
The method requires data on the monotherapy responses and the package
accommodates both checkerboard and ray designs. Functions are available for
graphical exploration of model goodness-of-fit and diagnostics, as well as
for synergy/antagonism assessment in 2D and 3D.

Maxim Nazarov

drugCombo

Drug Interaction Modeling Based on Loewe Additivity Following
Harbron's Approach

fitPlot3d function

A <code>HarbronFit</code> object returned by 
<code><a rd-options='' href='fitModel'>fitModel</a></code>.

fitPlot3d: Plot 3d surface of observations and model fit

Description

Usage

Arguments

Value