getBootTaus

A <code>HarbronFit</code> object returned by 
<code><a rd-options="" href="/link/fitModel?package=drugCombo&version=1.2.1" data-mini-rdoc="drugCombo::fitModel">fitModel</a></code>.

Number of bootstrap samples to use.

niter

Resampling method for bootstrap. Either "all" (default) for 
resampling from all data, "mono" for separately resampling monotherapy and 
combination data, or "stratified" for resampling at each dose combination 
separately. Note that the latter method is not meaningful if there are no 
replicates in the data.

resample

seed

Whether to show progress information.

verbose

Further arguments passed to the <code><a rd-options="" href="/link/fitModel?package=drugCombo&version=1.2.1" data-mini-rdoc="drugCombo::fitModel">fitModel</a></code> calls.

Function to run nonparametric bootstrap on the interaction index model.
It is usually called from <code><a rd-options="" href="/link/getTauSurface?package=drugCombo&version=1.2.1" data-mini-rdoc="drugCombo::getTauSurface">getTauSurface</a></code>.

Perform assessment of synergy/antagonism for drug combinations based
on the Loewe additivity model, following Harbron's approach (Statistics in
Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling
of the drug interaction index and supports "2-stage" estimation in addition
to "1-stage" estimation, including bootstrap-based confidence intervals.
The method requires data on the monotherapy responses and the package
accommodates both checkerboard and ray designs. Functions are available for
graphical exploration of model goodness-of-fit and diagnostics, as well as
for synergy/antagonism assessment in 2D and 3D.

Maxim Nazarov

drugCombo

Drug Interaction Modeling Based on Loewe Additivity Following
Harbron's Approach

getBootTaus function

A <code>HarbronFit</code> object returned by 
<code><a rd-options='' href='fitModel'>fitModel</a></code>.

Further arguments passed to the <code><a rd-options='' href='fitModel'>fitModel</a></code> calls.

Function to run nonparametric bootstrap on the interaction index model.
It is usually called from <code><a rd-options='' href='getTauSurface'>getTauSurface</a></code>.

getBootTaus: Run nonparametric bootstrap on the interaction index model

Description

Usage

Arguments

Value