invL4

Hill's coefficient (slope of the curve).

Maximal/asymptote effect (at infinite dose).

Point of inflection (in logarithmic terms).

logEC50

Inverse 4-parameter log-logistic (response-dose) function

Perform assessment of synergy/antagonism for drug combinations based
on the Loewe additivity model, following Harbron's approach (Statistics in
Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling
of the drug interaction index and supports "2-stage" estimation in addition
to "1-stage" estimation, including bootstrap-based confidence intervals.
The method requires data on the monotherapy responses and the package
accommodates both checkerboard and ray designs. Functions are available for
graphical exploration of model goodness-of-fit and diagnostics, as well as
for synergy/antagonism assessment in 2D and 3D.

invL4: Inverse 4-parameter log-logistic (response-dose) function

Description

Usage

Arguments

Value