rayData

A dataset containing data from an in-vitro drug combination experiment in 
oncology using a ray design. The variables are as follows:

Perform assessment of synergy/antagonism for drug combinations based
on the Loewe additivity model, following Harbron's approach (Statistics in
Medicine, 2010, <doi:10.1002/sim.3916>). The package allows flexible modeling
of the drug interaction index and supports "2-stage" estimation in addition
to "1-stage" estimation, including bootstrap-based confidence intervals.
The method requires data on the monotherapy responses and the package
accommodates both checkerboard and ray designs. Functions are available for
graphical exploration of model goodness-of-fit and diagnostics, as well as
for synergy/antagonism assessment in 2D and 3D.

Maxim Nazarov

drugCombo

Drug Interaction Modeling Based on Loewe Additivity Following
Harbron's Approach

rayData function

A data frame with 378 observations of 4 variables:<ul>
<li>d1: dose of the first compound</li>
<li>d2: dose of the second compound</li>
<li>effect: observed effect (radioactivity level)</li>
<li>ray: a character vector with values 0, 0.2, 0.35, 0.5, 
0.65, 0.8 and 1, corresponding to the mixture factors. Each ray has 9 dose 
combinations with 6 replicates.</li>
</ul>

rayData: Example ray design drug combination data

Description

Arguments

Format