drugdevelopR (version 1.0.2)

Ess_binary: Expected sample size for phase III for multiarm programs with binary distributed outcomes

Description

Given phase II results are promising enough to get the "go"-decision to go to phase III this function now calculates the expected sample size for phase III given the cases and strategies listed below. The results of this function are necessary for calculating the utility of the program, which is then in a further step maximized by the optimal_multiarm_binary() function

Usage

Ess_binary(RRgo, n2, alpha, beta, p0, p11, p12, strategy, case)

Value

the function Ess_binary() returns the expected sample size for phase III when going to phase III

Arguments

RRgo

threshold value for the go/no-go decision rule

n2

total sample size for phase II; must be even number

alpha

significance level

beta

1-beta power for calculation of sample size for phase III

p0

assumed true rate of control group

p11

assumed true rate of treatment group

p12

assumed true rate of treatment group

strategy

choose Strategy: 1 ("only best promising"), 2 ("all promising") or 3 (both)

case

different cases: 1 ("nogo"), 21 (treatment 1 is promising, treatment 2 is not), 22 (treatment 2 is promising, treatment 1 is not), 31 (both treatments are promising, treatment 1 is better), 32 (both treatments are promising, treatment 2 is better)

Examples

res <- Ess_binary(RRgo = 0.8 ,n2 = 50 ,alpha = 0.05, beta = 0.1,
                            p0 = 0.6, p11 =  0.3, p12 = 0.5,strategy = 3, case = 31)