dtComb (version 1.0.7)

helper_PT: Helper function for PT method.

Description

The helper_PT function estimates the optimized value of given biomarkers for the PT method.

Usage

helper_PT(lambda, neg.set, pos.set)

Value

A numeric value for the estimated optimized value

Arguments

lambda

a numeric parameter that will be estimated in minmax method for the combination score

neg.set

a numeric data frame that contains the observation with negative status

pos.set

a numeric data frame that contains the observation with positive status

Author

Serra Ilayda Yerlitas, Serra Bersan Gengec, Necla Kochan, Gozde Erturk Zararsiz, Selcuk Korkmaz, Gokmen Zararsiz

Examples

# call data
data(laparotomy)

# define the function parameters
markers <- cbind(laparotomy$ddimer, laparotomy$log_leukocyte)
status <- factor(laparotomy$group, levels = c("not_needed", "needed"))

neg.set <- markers[status == levels(status)[1], ]
pos.set <- markers[status == levels(status)[2], ]

lambda <- 0.5

stat <- helper_PT(lambda, neg.set = neg.set, pos.set = pos.set)