dtComb (version 1.0.7)

helper_TS: Helper function for TS method.

Description

The helper_TS function calculates the combination coefficient and optimized value of given biomarkers for the TS method.

Usage

helper_TS(theta, markers, status)

Value

A numeric Optimized value calculated with combination scores using theta

Arguments

theta

a numeric parameter that will be estimated in TS method for the combination score

markers

a numeric data frame that contains the biomarkers

status

a factor data frame that includes the actual disease status of the patients

Author

Serra Ilayda Yerlitas, Serra Bersan Gengec, Necla Kochan, Gozde Erturk Zararsiz, Selcuk Korkmaz, Gokmen Zararsiz

Examples

# call data
data(laparotomy)

# define the function parameters
markers <- cbind(laparotomy$ddimer, laparotomy$log_leukocyte)
status <- factor(laparotomy$group, levels = c("not_needed", "needed"))

t <- 0.5

stat <- helper_TS(theta = t, markers = markers, status = status)