# Plot an approximate 95\% confidence region for the Puromycin
# parameters Vm and K, and overlay the ellipsoidal region
library(nls)
data(Puromycin)
Purboth <- nls(formula = rate ~ ((Vm + delV * (state == "treated"))
* conc)/(K + conc), data = Puromycin,
start = list(Vm = 160, delV = 40, K = 0.05))
Pur.prof <- profile(Purboth)
plot(ellipse(Pur.prof, which = c('Vm', 'K')), type = 'l')
lines(ellipse(Purboth, which = c('Vm', 'K')), lty = 2)
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