Learn R Programming

episcan (version 0.0.1)

Scan Pairwise Epistasis

Description

Searching genomic interactions with linear/logistic regression in a high-dimensional dataset is a time-consuming task. This package provides some efficient ways to scan epistasis in genome-wide interaction studies (GWIS). Both case-control status (binary outcome) and quantitative phenotype (continuous outcome) are supported (the main references: 1. Kam-Thong, T., D. Czamara, K. Tsuda, K. Borgwardt, C. M. Lewis, A. Erhardt-Lehmann, B. Hemmer, et al. (2011). . 2. Kam-Thong, T., B. Ptz, N. Karbalai, B. Mller-Myhsok, and K. Borgwardt. (2011). .)

Copy Link

Version

Install

install.packages('episcan')

Monthly Downloads

31

Version

0.0.1

License

GPL (>= 2)

Maintainer

Beibei Jiang

Last Published

September 14th, 2018

Functions in episcan (0.0.1)

WriteSnpPairs

Write out epistasis result (normal matrix)
WriteSnpPairs_sym

Write out epistasis result (symmetric matrix)
ZtoP

Convert Z-score to correponding p-value
epiHSIC2genos

Calculate epistasis using HSIC with two genotype inputs
checkchunksize

Check chunk size
epiblaster1geno

Parallelized calculation of the difference of correlation coefficients and compute \(Z\) test with one genotype input
getcor

Get correlation matrix
ithChunk

index set for idx-th chunk of size chunk for n elements
epiHSIC

Calculate HSIC values
epiblaster2genos

Parallelized calculattion of the difference of correlation coefficients and compute Z test with two genotype inputs
epiHSIC1geno

Calculate epistasis using HSIC with one genotype input
episcan

Scan pairwise epistasis