esDesign (version 1.0.3)

SD.sim: Conduct the simulation studies of the standard design

Description

The SD.sim() is used to implement the simulation studies of the standard design.

Usage

SD.sim(N, rho, alpha, beta, theta, theta0, sigma0, nSim, Seed)

Arguments

N

The total sample size required

rho

The proportion of subgroup 1

alpha

The overall Type I error rate

beta

The (1 -Power)

theta

The sizes of treatment effects for subgroups 1 and 2 in experimental arm

theta0

The size of treatment effect for the control arm

sigma0

The variance of the treatment effect

nSim

The number of simulated studies

Seed

The random seed

Value

A list contains,

• nTotal the total sample used

• The power of the specified trial. Here, the power is defined as the probability of rejecting the null hypothesis.

Examples

# NOT RUN {
N <- 620
rho <- 0.5
alpha <- 0.05
beta <- 0.2
theta <- c(0.2,0.0)
theta0 <- 0
sigma0 <- 1
nSim <- 1000
Seed <- 6
SD.sim(N = N, rho = rho,
       alpha = alpha, beta = beta, theta = theta, theta0 = theta0,
       sigma0 = sigma0, nSim = nSim, Seed = Seed)

# }