empiric_eff_rate

Get the empirical or observed efficacy rate seen at each dose under
investigation. This is simply the number of efficacies divded by the number
of patients evaluated.

Methods for working with dose-finding clinical trials. We provide
implementations of many dose-finding clinical trial designs, including the
continual reassessment method (CRM) by O'Quigley et al. (1990)
<doi:10.2307/2531628>, the toxicity probability interval (TPI) design by Ji
et al. (2007) <doi:10.1177/1740774507079442>, the modified TPI (mTPI) design
by Ji et al. (2010) <doi:10.1177/1740774510382799>, the Bayesian optimal
interval design (BOIN) by Liu & Yuan (2015) <doi:10.1111/rssc.12089>, EffTox
by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the design of
Wages & Tait (2015) <doi:10.1080/10543406.2014.920873>, and the 3+3
described by Korn et al. (1994) <doi:10.1002/sim.4780131802>. All designs
are implemented with a common interface. We also offer optional additional
classes to tailor the behaviour of all designs, including avoiding skipping
doses, stopping after n patients have been treated at the recommended dose,
stopping when a toxicity condition is met, or demanding that n patients are
treated before stopping is allowed. By daisy-chaining together these classes
using the pipe operator from 'magrittr', it is simple to tailor the
behaviour of a dose-finding design so it behaves how the trialist wants.
Having provided a flexible interface for specifying designs, we then provide
functions to run simulations and calculate dose-paths for future cohorts of
patients.

Kristian Brock

escalation

A Modular Approach to Dose-Finding Clinical Trials

Daniel Slade

Michael Sweeting

empiric_eff_rate function

<dl><dt>x</dt>
<dd>Object of class <code>selector</code></dd>
<dt>...</dt>
<dd>arguments passed to other methods</dd></dl>

Arguments

Observed efficacy rate at each dose. — empiric_eff_rate

<dl>

<dt>x</dt>
<dd>Object of class <code>selector</code></dd>


<dt>...</dt>
<dd>arguments passed to other methods</dd>

</dl>

empiric_eff_rate: Observed efficacy rate at each dose.

Description

Usage

Value

Arguments

Examples