get_boin

Get an object to fit the BOIN model using the BOIN package.

Methods for working with dose-finding clinical trials. We provide
implementations of many dose-finding clinical trial designs, including the
continual reassessment method (CRM) by O'Quigley et al. (1990)
<doi:10.2307/2531628>, the toxicity probability interval (TPI) design by Ji
et al. (2007) <doi:10.1177/1740774507079442>, the modified TPI (mTPI) design
by Ji et al. (2010) <doi:10.1177/1740774510382799>, the Bayesian optimal
interval design (BOIN) by Liu & Yuan (2015) <doi:10.1111/rssc.12089>, EffTox
by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the design of
Wages & Tait (2015) <doi:10.1080/10543406.2014.920873>, and the 3+3
described by Korn et al. (1994) <doi:10.1002/sim.4780131802>. All designs
are implemented with a common interface. We also offer optional additional
classes to tailor the behaviour of all designs, including avoiding skipping
doses, stopping after n patients have been treated at the recommended dose,
stopping when a toxicity condition is met, or demanding that n patients are
treated before stopping is allowed. By daisy-chaining together these classes
using the pipe operator from 'magrittr', it is simple to tailor the
behaviour of a dose-finding design so it behaves how the trialist wants.
Having provided a flexible interface for specifying designs, we then provide
functions to run simulations and calculate dose-paths for future cohorts of
patients.

Kristian Brock

escalation

A Modular Approach to Dose-Finding Clinical Trials

Daniel Slade

Michael Sweeting

get_boin function

<dl><dt>num_doses</dt>
<dd>Number of doses under investigation.</dd>
<dt>target</dt>
<dd>We seek a dose with this probability of toxicity.</dd>
<dt>use_stopping_rule</dt>
<dd>TRUE to use the toxicity stopping rule described in
Yan et al. (2019). FALSE to suppress the authors' stopping rule, with the
assumption being that you will test the necessity to stop early in some other
way.</dd>
<dt>...</dt>
<dd>Extra args are passed to <code>get.boundary</code>.</dd></dl>

Arguments

Get an object to fit the BOIN model using the BOIN package. — get_boin

<dl>

<dt>num_doses</dt>
<dd>Number of doses under investigation.</dd>


<dt>target</dt>
<dd>We seek a dose with this probability of toxicity.</dd>


<dt>use_stopping_rule</dt>
<dd>TRUE to use the toxicity stopping rule described in
Yan et al. (2019). FALSE to suppress the authors' stopping rule, with the
assumption being that you will test the necessity to stop early in some other
way.</dd>


<dt>...</dt>
<dd>Extra args are passed to <code>get.boundary</code>.</dd>

</dl>

get_boin: Get an object to fit the BOIN model using the BOIN package.

Description

Usage

Value

Arguments

References

Examples