predictEvents

Based on a specified survival function and potential future accrual, compute for each month in the future the number of expected events reached by then.

htest

Implements the hybrid framework for event prediction described in Fang & Zheng (2011, <doi:10.1016/j.cct.2011.05.013>). To estimate the survival function the event prediction is based on, a piecewise exponential hazard function is fit to the time-to-event data to infer the potential change points. Prior to the last identified change point, the survival function is estimated using Kaplan-Meier, and the tail after the change point is fit using piecewise exponential.

Kaspar Rufibach

eventTrack

Event Prediction for Time-to-Event Endpoints

predictEvents function

<dl> <dt>time</dt>
<dd>Event times, censored or observed, in months.</dd> <dt>event</dt>
<dd>Censoring indicator, 1 for event, 0 for censored.</dd> <dt>St</dt>
<dd>Function that specifies the survival function to be used.</dd> <dt>accrual</dt>
<dd><code>NULL</code> if trial is fully accrued. For potential future accural, see example in <code>hybrid_Exponential</code> of how to specify it.</dd> <dt>future.units</dt>
<dd>Number of future months to compute prediction for.</dd></dl>

Arguments

Kaspar Rufibach (maintainer) <a href="/link/kaspar.rufibach%40roche.com?package=eventTrack&version=1.0.4" data-mini-rdoc="eventTrack::kaspar.rufibach@roche.com">kaspar.rufibach@roche.com</a>

Author

Compute timepoint when a certain number of events in a time-to-event study is reached — predictEvents

<dl>

 <dt>time</dt>
<dd>Event times, censored or observed, in months.</dd>

 <dt>event</dt>
<dd>Censoring indicator, 1 for event, 0 for censored.</dd>

 <dt>St</dt>
<dd>Function that specifies the survival function to be used.</dd>

 <dt>accrual</dt>
<dd><code>NULL</code> if trial is fully accrued. For potential future accural, see example in <code>hybrid_Exponential</code> of how to specify it.</dd>

 <dt>future.units</dt>
<dd>Number of future months to compute prediction for.</dd>

</dl>

Kaspar Rufibach (maintainer) <a href='mailto:kaspar.rufibach@roche.com'>kaspar.rufibach@roche.com</a>

predictEvents: Compute timepoint when a certain number of events in a time-to-event study is reached

Description

Usage

Value

Arguments

Author

References

Examples