ewoc (version 0.3.0)

dlt_curve_d1ph: Plot the DLT curve based on the EWOC proportional hazards model

Description

Plot the DLT curve based on the EWOC proportional hazards model

Usage

dlt_curve_d1ph(
  mtd,
  rho,
  theta,
  min_dose,
  max_dose,
  shape,
  tau,
  distribution = "exponential",
  dose_set = NULL
)

Arguments

mtd

a numerical value indicating the true value of the parameter mtd.

rho

a numerical value indicating the true value of the parameter rho.

theta

a numerical value defining the proportion of expected patients to experience a medically unacceptable, dose-limiting toxicity (DLT) if administered the MTD.

min_dose

a numerical value defining the lower bound of the support of the MTD.

max_dose

a numerical value defining the upper bound of the support of the MTD.

shape

a numerical value indicating the true value of the parameter shape. It is only necessary if 'distribution' = "weibull".

tau

a numerical value defining the period of time for a possible toxicity be observed.

distribution

a character establishing the distribution for the time of events. It can be defined as 'exponential' or 'weibull'.

dose_set

a numerical vector of doses that probability of DLT will be calculated.