mtd_rho_d1extended

a numerical value defining the mtd value to be converted into rho_1 value.

a numerical value defining the probability of DLT at the max_dose.

rho_1

a numerical value defining the probability of DLT at the min_dose.

rho_0

a numerical value defining the proportion of expected patients
to experience a medically unacceptable, dose-limiting toxicity (DLT) if
administered the MTD.

theta

a numerical value defining the lower bound of the support of
the MTD.

min_dose

a numerical value defining the upper bound of the support of
the MTD.

max_dose

Converting mtd to rho_1 given rho_0 for EWOC design using extended parametrization
and vice-versa.

An implementation of a variety of escalation with overdose control designs introduced by Babb, Rogatko and Zacks (1998) <doi:10.1002/(SICI)1097-0258(19980530)17:10%3C1103::AID-SIM793%3E3.0.CO;2-9>. It calculates the next dose as a clinical trial proceeds and performs simulations to obtain operating characteristics.

mtd_rho_d1extended: Convert mtd to rho_1 and vice-versa

Description

Usage

Arguments

Value